肥胖对肺高血压死亡率的影响-系统性审查和元分析
Raju Reddy1, Saminder Singh Kalra2, Bashar Alzghoul2
1Division of Pulmonary and Critical Care Medicine, University of Texas at Austin, Austin, TX 78712, USA.
Journal of cardiovascular development and disease
|October 27, 2023
概括
肥胖悖论表明,肥胖可能会防止肺高血压 (PH) 的死亡. 这次元分析发现,肥胖与PH患者的死亡率降低有关,支持了悖论.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肺高血压 (PH) 是一种严重的疾病,死亡率高.
- "肥胖悖论"描述了某些疾病的肥胖患者的潜在生存益处,包括PH.
- 关于肥胖对PH死亡率的影响的现有研究是矛盾的.
研究的目的:
- 系统地审查和对现有关于肥胖与PH患者死亡率之间的关联的研究进行元分析.
- 为了研究PH的肥胖悖论,使用诊断为右心导管患者的数据.
- 进行分组分析,重点关注毛囊前PH.
主要方法:
- 发表的研究的系统审查和元分析.
- 纳入标准:通过右心导管检查进行PH诊断.
- 分析了6项研究,共有13,987名患者参与,其中包括毛细血管前PH的子组.
主要成果:
- 结合毛细血管前后PH的肥胖患者的死亡率显著降低 (HR 0.79,p=0.01).
- 在毛囊前PH小组中,肥胖也与死亡率降低有关 (HR 0.77,p=0.03).
- 肥胖和减少死亡率之间的观察到的关联在所有纳入研究中都不一致.
结论:
- 这些发现支持肺高血压中肥胖悖论,表明肥胖患者的潜在生存益处.
- 肥胖与联合和毛囊前PH组的死亡率降低有关.
- 需要进一步的研究来理解机制,并确认这种效应在研究中的不均性.
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