新兴的单原子纳米酶用于高效的细菌消除
Tongyu Shi1, Yuanyuan Cui1, Huanxiang Yuan1
1Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Nanomaterials (Basel, Switzerland)
|October 27, 2023
概括
单原子纳米酶 (SAzymes) 通过产生反应性氧物种,为抗药性细菌感染提供了有效的解决方案. 本综述强调了它们的先进抗菌应用和未来潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性需要新的抗菌策略.
- 纳米酶显示出作为抗生素替代品的希望,因为其高效率和低耐药性风险.
- 目前,不足的催化活性限制了细菌感染中纳米酶的发展.
研究的目的:
- 审查用于抗菌应用的单原子纳米酶 (SAzymes) 的最新进展.
- 讨论SAzymes在治疗细菌感染中的作用机制.
- 探索SAzymes在临床环境中的挑战和未来前景.
主要方法:
- 关于SAzymes及其抗菌性能的最新研究的文献综述.
- 对SAzyme催化机制的分析,重点关注反应性氧物种的产生.
- 检查SAzyme在伤口消毒,骨髓炎治疗和海洋抗生素污染中的应用.
主要成果:
- 由于最大限度的原子利用和分散的活性金属位点,SA酶表现出优越的酶类活动.
- 在各种抗菌应用中,SA酶已经显示出显著的有效性.
- 该审查综合了关于SAzyme性能和机制的当前知识.
结论:
- 赛亚酶是一种高效且有前途的抗菌剂.
- 需要进一步的研究,以克服SAzymes在实践和广泛应用方面的挑战.
- 赛亚酶具有与抗生素耐药性细菌感染作斗争的巨大潜力.
相关概念视频
Biological Methods for Microbial Control
42
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
42
Chemical Agents for Microbial Control
38
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
38
Physical Methods for Controlling Microbial Growth: Radiation and Filtration
35
Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
35
Gene Regulation in Microbial Communities: Quorum Sensing
23
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
23


