水醇凝中的过敏原和其他有害物质:遵守现行法规
Ana Castiñeira-Landeira1, Lua Vazquez1, Thierry Dagnac2
1CRETUS, Department of Analytical Chemistry, Nutrition and Food Science, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Methods and protocols
|October 27, 2023
概括
手部消毒剂含有众多化品成分,包括香气过敏原和禁止的塑化剂. 许多产品不符合欧盟化品法规,对消费者构成潜在风险.
科学领域:
- 分析化学 分析化学
- 化品科学 化品科学
- 监管合规性 监管合规性
背景情况:
- 酒精凝 (手部消毒剂) 对于预防COVID-19传播至关重要.
- 这些产品可以被归类为化品或生物杀菌剂,需要监管监督.
- 对于化品配方中未申报或受限制化学品的存在存在存在担忧.
研究的目的:
- 为了识别和量化60个个人护理化合物在手部消毒剂.
- 评估这些产品的监管符合欧盟化品法规.
- 评估使用的分析方法的可持续性.
主要方法:
- 开发和验证固态微提取 (SPME) 方法的开发和验证.
- 气色谱-并联质谱 (GC-MS/MS) 用于化合物检测.
- 分析了67个现实世界手部消毒剂样本.
主要成果:
- 在60种目标化合物中,47种被检测到在分析的手部消毒剂中.
- 发现了高度的气味过敏原 (高达23个),达到32,458μg-1 .
- 广泛违反欧盟第1223/2009号法规的标签要求;还检测到禁止的增塑剂.
结论:
- 许多手部消毒剂含有大量未申报的化品成分,包括过敏原.
- 监管不合规和禁止物质的存在凸显了安全问题.
- 经过验证的SPME-GC-MS/MS方法是有效和环境可持续的,用于分析手部消毒剂中的化品成分.
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