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开发固体脂质纳米粒子用于控制的阿米奥达龙输送

Andreea Creteanu1, Gabriela Lisa2, Cornelia Vasile3

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.

Methods and protocols
|October 27, 2023
PubMed
概括

这项研究开发了含有阿米奥达龙的固体脂质纳米颗粒 (AMD-SLNs),以提高阿米奥达龙化的溶解性和口服输送. 该P5配方表现出控制药物释放的最佳特性.

关键词:
一个朋友,一个朋友,一个朋友.控制的交付控制的交付.固体脂质纳米粒子 固体脂质纳米粒子

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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