化合物对两个细胞因子风暴玩家的选择性影响
Indu Sinha1, Junjia Zhu2, Raghu Sinha1
1Department of Biochemistry and Molecular Biology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
Journal of personalized medicine
|October 27, 2023
概括
化合物,特别是甲基酸 (MSeA),可以减少关键的细胞因子风暴参与者,如IL-6和TNF-α. 这表明MSeA可能是COVID-19治疗策略的有益补充.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 细胞因子风暴是COVID-19的严重并发症,导致器官损伤.
- 目前对细胞因子风暴的治疗方法取得的成功有限.
- 介乐-6 (IL-6) 和瘤坏死因子-α (TNF-α) 是细胞因子风暴的关键调解者.
研究的目的:
- 为了评估化合物在体外减轻细胞因子风暴的潜力.
- 为了研究甲基烯酸 (MSeA) 降低IL-6和TNF-α分泌的疗效.
- 探索MSeA的分子机制,包括它对Nrf2和IκBα通路的影响.
主要方法:
- 使用THP-1巨细胞对四种化合物的体外评估.
- 脂聚糖 (LPS) 的挑战是诱导细胞因子的产生.
- 对IL-6和TNF-α水平的测量.
- 在MSeA治疗后对Nrf2和IκBα蛋白水平的分析.
主要成果:
- 甲基酸 (MSeA) 在测试的化合物中显示出对IL-6和TNF-α分泌的最显著降低.
- 在人类巨细胞中,MSeA治疗导致了Nrf2激活的增加和酸化IκBα (pIκBα) 的减少.
- 这些发现凸显了MSeA强大的抗炎作用.
结论:
- ,特别是MSeA,在抑制细胞因子风暴的关键媒介方面表现有前途.
- 通过减少有害的炎症反应,MSeA可能为COVID-19患者提供治疗效益.
- 需要对MSeA作为COVID-19的辅助疗法进行进一步的临床研究.
关键词:
在 COVID-19 疫情中,细胞因子风暴是什么意思细胞因子 细胞因子甲基烯酸是一种甲基烯酸.单甲氨酸 (Selenomethionine) 是一种含有氨酸的物质.酸是一种酸.的化 (Selenite) 是一种更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
476
06:37Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
Published on: September 15, 2023
638
相关概念视频
01:25Selectins
3.3K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.3K
01:20The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
01:15Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K