大规模大脑网络的功能障碍是轮班工作障碍的潜在认知障碍
Yan Zhao1,2, Sitong Feng1,2, Linrui Dong1,2
1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospitaldiscu, Capital Medical University, Beijing, China.
轮班工作障碍 (SWD) 通过改变大规模的大脑网络连接来破坏认知功能. 这些大脑网络变化与SWD患者的记忆和视觉空间障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 医疗成像医学成像
背景情况:
- 众所周知,轮班工作会影响认知功能.
- 神经成像研究表明,轮班工作障碍 (SWD) 中的大脑结构和功能发生了变化.
- 了解SWD中大规模的大脑网络功能障碍对于解释认知缺陷至关重要.
研究的目的:
- 识别与SWD认知衰退相关的功能性脑网络变化.
- 评估这些网络变化的诊断潜力.
主要方法:
- 招募了34名SWD患者和36名健康对照 (HC).
- 用于评估神经心理状态的可重复电池 (RBANS) 和休息状态的功能性MRI.
- 使用Dosenbach atlas分析了网络内部和网络之间的功能连接 (FC).
主要成果:
- 在SWD患者中,网络内部的FC和网络间的FC变化增加 (例如,VAN-SCN,SCN-FPN).
- 在SWD中观察到网络间FC降低,特别是涉及默认模式网络 (DMN).
- 改变的FC与SWD中的即时记忆,视觉空间和延迟记忆得分有显著的相关性.
结论:
- 大规模大脑网络中的异常功能连接与SWD的认知功能障碍有关.
- 这些发现提供了关于轮班工作障碍中认知障碍背后的神经机制的见解.
- 识别的网络中断可能对SWD具有诊断价值.
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