可吸收板是否比植入物更耐感染? 一个实验性的临床前试验在子
Dimitrios Kitridis1, Panagiotis Savvidis1, Angeliki Cheva2
11st Orthopaedic Department, School of Medicine, Faculty of Health Science, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Journal of functional biomaterials
|October 27, 2023
概括
在子骨折模型中,可吸收植入物与植入物相比,感染率明显较低. 虽然可吸收材料降低了感染风险,但它们可能会引起异物反应,需要进一步干预.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学是生物材料的科学.
- 传染病 传染病 传染病 传染病
背景情况:
- 手术后感染是骨科植入物的重要并发症.
- 正在研究可吸收材料作为金属植入物的替代品,以减少感染率.
研究的目的:
- 在临床前的子模型中,比较可吸收的共聚合物植入物和植入物之间的感染率.
- 评估可吸收植入物在骨折内部固定后预防感染的有效性.
主要方法:
- 在60只子中,使用股骨骨折建立了与植入物相关的试验性感染模型.
- 动物接受了板和螺丝 (A组) 或可吸收板和螺丝 (B组).
- 植入物被注射了Pseudomonas Aeruginosa,并评估了感染率,临床症状,实验室标记物,放射学,组织学和培养物.
主要成果:
- 在可吸收植入物组 (13.3%) 的感染发病率明显低于组 (36.7%) (p=0.04).
- 在16.7%的可吸收植入物动物中观察到异物反应,其特征是炎症标志物升高,但没有同时感染 (p=0.04).
- 在感染或异物反应的动物中观察到骨重塑的放射性迹象.
结论:
- 与植入物相比,可吸收板和螺丝显示感染易感性降低.
- 可吸收植入物的使用可能与异物反应有关,可能需要额外的外科手术程序.
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