根修复水泥的抗菌活性与Dentin-An活体研究接触
Andreas Koutroulis1, Håkon Valen2, Dag Ørstavik1
1Section of Endodontics, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, 0317 Oslo, Norway.
Journal of functional biomaterials
|October 27, 2023
概括
这项研究发现,使用银纳米粒子 (SNP) 的实验液压酸盐水泥 (HCSC) 显示出强烈的抗菌作用. 生物活性玻璃 (BG) 降低了HCSC.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 微生物学 微生物学
背景情况:
- 牙材料必须具有抗菌性质,以防止二次感染.
- 液压酸盐水泥 (HCSC) 是有希望的,但需要对其抗菌有效性的评估.
- 生物活性玻璃 (BG) 和银纳米粒子 (SNP) 等添加剂对水泥抗菌活性的影响需要澄清.
研究的目的:
- 评估牙/材料接口和牙表面的抗菌特性,这些牙表面被暴露在与BG或SNP的实验HCSC中.
- 为了比较HCSC配方的抗菌活性与商业材料如Biodentine,TotalFill BC RRM膏和IRM.
- 评估相互作用时间对这些材料抗菌潜力的影响.
主要方法:
- 人类根牙细分被暴露在HCSC (20%或40%的BG替代或1或2毫克/毫升SNP),Biodentine,TotalFill BC RRM膏和IRM中1或28天.
- 使用直接接触测试对Enterococcus faecalis和Pseudomonas aeruginosa生物膜进行了抗菌活性测试.
- 在3天的生物膜暴露后,孔焦显微镜评估了牙/材料接口的抗菌活性.
主要成果:
- 在一天的评估中,所有测试材料在牙表面表现出抗菌性质.
- 与其他测试材料相比,使用40%的BG替代品,Biodentine和IRM的HCSC显示抗菌性能降低.
- 2 mg/mL SNP 的 HCSC 在对焦试验中表现出最高的抗菌作用,具有更长的暴露时间的增强潜力.
结论:
- 测试材料,包括HCSC配方,在相邻的牙上赋予了抗菌活性.
- 生物活性玻璃 (BG) 替代剂降低了HCSC暴露的牙的抗菌作用.
- 添加银纳米粒子 (SNP),特别是2 mg/mL,显著增强了HCSC的抗菌潜力,特别是更长的相互作用时间.
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