双重交叉链接的奇托/细菌纤维素包裹具有自我愈合的能力
Lili Deng1, Kangkang Ou1, Jiaxin Shen1
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
Gels (Basel, Switzerland)
|October 27, 2023
概括
这项研究介绍了一种全天然的,自我愈合的水凝,用于伤口愈合. 生物相容的CSMA/DABC水凝表现出快速的自我修复和优良的机械性能,显示出用于组织修复应用的巨大潜力.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 聚合物化学 聚合物化学
背景情况:
- 自愈的水凝对于先进的伤口愈合应用至关重要.
- 现有的水凝往往缺乏生物相容性或有效的自我修复机制.
- 自然聚合物为开发先进的伤口护理材料提供了有希望的替代品.
研究的目的:
- 开发一种全天然的,自我愈合的水凝,用于伤口愈合.
- 为了利用甲基化基 (CSMA) 和二甲细菌纤维素 (DABC) 形成水凝.
- 评估开发的水凝的自我愈合,机械和细胞兼容性特性.
主要方法:
- 酸盐 (CS) 用甲烯酸无水化物 (MA) 进行了修改,以创建CSMA.
- 细菌纤维素 (BC) 被氧化,引入二甲基组,形成DABC.
- 水凝通过CSMA和DABC之间的希夫基反应形成,由FTIR证实.
- 扫描电子显微镜 (SEM) 用于分析水凝微观结构.
- 测量了压力强度和膨胀比率.
- 在体外细胞相容性使用细胞活力试验进行了评估.
主要成果:
- FTIR证实了CS和BC的成功修改.
- 通过可逆的希夫基键,CSMA/DABC水凝迅速 (11分钟) 形成.
- 宏观和显微观测证实了极好的自我愈合能力.
- SEM揭示了一个均的,多孔结构与分布良好的DABC纳米纤维.
- 水凝的压力强度>20kPa,膨胀率>10倍.
- 细胞活力保持在90%以上,表明细胞兼容性良好.
结论:
- 通过使用CSMA和DABC成功开发了一种全天然的,自我愈合的水凝.
- 水凝具有强大的自我愈合特性,有利的机械强度和高膨胀能力.
- 该材料表现出极好的细胞兼容性,使其成为治疗伤口和组织修复的有希望的候选者.
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