含有蔓越提取物的食用凝:对安托素释放动态的评估
Rima Šedbarė1, Valdimaras Janulis1, Kristina Ramanauskiene2
1Department of Pharmacognosy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Gels (Basel, Switzerland)
|October 27, 2023
概括
从口服凝中释放的蔓越安托西亚尼因聚合物而异. 基托桑凝显示出最快和最高的抗生素释放率,表明这些抗氧化化合物的有效输送潜力.
科学领域:
- 药理学和制药学 药理学和制药学
- 自然产品化学 自然产品化学
- 食品科学 食品科学 食品科学
背景情况:
- 蔓越果含有具有健康益处的生物活性抗氧化剂,包括降低慢性疾病和感染风险.
- 口服凝为蔓越提取物提供了一个有前途的输送系统,确保精确的剂量和适合食障碍患者.
- 了解这些凝配方中活性化合物的释放动力学对于优化其治疗潜力至关重要.
研究的目的:
- 为了研究不同聚合物材料对来自蔓越果提取物凝配方中安东素的溶解动力学的影响.
- 为了比较基于奇托,碳酸甲基纤维素和与碳燃烧剂组合的凝中的安东素的释放概况.
主要方法:
- 制备9种凝配方 (G1-G9),使用冷干燥的蔓越水果提取物和各种凝剂 (奇托,氧化甲基纤维素,卡博默).
- 溶解测试从凝配方中释放的安东素.
- 用水友膜分析随着时间的推移释放到接受媒介中的安托西亚宁含量.
主要成果:
- 在最初的10分钟内,奇托和碳素甲基纤维素凝 (G1-G6,G9) 的安托西亚宁释放速度很快,其进一步释放有限.
- 含有氧甲基纤维素和碳化合物 (G7-G8) 的凝呈现出反素释放的逐渐增加,延长释放时间.
- 1%的酸盐凝 (G1) 显示出最快和最高的抗生素释放率 (70%在6小时内),而其他配方释放的不到57%.
结论:
- 聚合物辅料显著影响口服凝配方中的蔓越安东的溶解动力学.
- 基托桑基的凝显示出快速和大量释放蔓越安东的优越潜力.
- 凝剂的选择对于控制口服输送系统中生物活性化合物的释放速度和持续时间至关重要.
相关概念视频
01:26EDTA: Auxiliary Complexing Reagents
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
01:18Effects of EDTA on End-Point Detection Methods
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...