斯皮兰塞斯·阿克梅拉 (Spilanthes acmella) 提取的天然油含有膜,用于抗皮肤炎的抗微生物作用
Aqsa Afzal1, Syed Nisar Hussain Shah2, Hina Javed1
1Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60000, Pakistan.
Gels (Basel, Switzerland)
|October 27, 2023
概括
这项研究开发了一种由Spilanthes acmella提取物用于细菌皮肤感染的草本乳化剂. 乳液表现出显著的抗菌活性和有效的皮肤透.
科学领域:
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
- 草药是一种草药.
背景情况:
- 皮肤炎经常因细菌,病毒和真菌感染而复杂化.
- 斯皮兰特斯·阿克梅拉提取物含有斯皮兰索,以其强大的抗菌特性而闻名.
- 抗微生物药物耐药性不断增加,需要针对皮肤感染采取新的治疗方法.
研究的目的:
- 为了制定和描述一种新的草本乳化剂,其中包括Spilanthes acmella提取物.
- 评估开发的乳化剂对常见的细菌皮肤病原体的疗效.
- 为了研究乳化剂作为细菌性皮肤炎的替代治疗方法的潜力.
主要方法:
- 使用Spilanthes acmella提取物制备了乳化剂,并以物理,质和生物粘合性特征进行了表征.
- 评估了抗菌活性针对金黄色葡萄球菌,Pseudomonas aeruginosa和大肠杆菌.
- 进行了体外药物溶解和体外皮肤透研究,以评估药物释放和透.
主要成果:
- F4乳化剂配方对具有显著抑制区的测试病原体表现出100%的抗菌活性.
- 统计学意义上的结果 (p=0.024对于S. aureus,p=0.001对于E. coli) 证实了强大的抗菌作用.
- F4配方实现了最大的百分比溶解 (86.35%),透率 (55.29%) 和流量 (0.5532 ug/cm2/min).
结论:
- 开发的Spilanthes acmella乳液是有效治疗细菌性皮肤感染的.
- 该配方在治疗因细菌感染而复杂的皮肤炎方面显示出有希望的结果.
- 该研究支持使用Spilanthes acmella提取物和橄油在皮肤病应用的乳化剂中.
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