酸功能四元化基托氧糖衍生物:制备,表征,抗氧化,抗菌和抗真菌活性
Yan Sun1,2,3, Jingmin Cui1,2, Liguang Tian4
1Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Marine drugs
|October 27, 2023
概括
新型基托醇糖 (COS) 衍生物被合成,具有增强的抗氧化,抗真菌和抗菌特性. 这些COS衍生品显示出在食品,医药和医疗保健行业的应用潜力.
科学领域:
- 生物化学 生物化学
- 有机化学 有机化学
- 材料科学 是一种材料科学.
背景情况:
- 甲基氧糖 (COS) 是一种有前途的生物材料,具有多种生物活性.
- 人们对开发具有增强功能的新型COS衍生品越来越感兴趣.
研究的目的:
- 合成和表征新型酸功能COS衍生物.
- 评估这些衍生物的体外抗氧化,抗真菌和抗菌活性.
主要方法:
- 用两个简单的方法合成十四种酸功能COS衍生物.
- 使用FT-IR和1H NMR光谱学进行结构性表征.
- 在体外测定抗氧化剂 (DPPH,超氧化物,基清除,降低功率),抗真菌 (对抗Botrytis cinerea和Fusarium graminearum) 和抗菌 (对抗大肠杆菌和金黄色葡萄球菌) 活动.
主要成果:
- 成功合成并对14种新的COS衍生品进行了表征.
- 衍生品表现出增强的抗氧化活性,特别是N,N,N-三甲基化基酸糖盐 (GLTMC),酸化N,N,N-三甲基化基酸糖 (GL-TMC) 和咖啡酸N,N,N-三甲基化基酸糖 (CFTMC).
- Salicylic 酸化 N,N,N-三甲基化基酸糖 (SY-TMC) 显示出针对 B. cinerea 和 F. graminearum 的显著抗真菌活性.
- 咖啡酸化N,N,N-三甲基化基醇糖 (CF-TMC) 显示对大肠杆菌和金黄色杆菌有抑制作用.
结论:
- 该研究提出了一种生产具有显著增强生物活性的COS衍生物的新方法.
- 这些COS衍生品在食品,医药和医疗保健产品行业具有应用潜力.
相关概念视频
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