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复星抗 Echinococcus sp. 的作用 : 在体外和体外反应之间的差异

Julia A Loos^1,2, Micaela Franco³, Maia Chop^2,4

¹Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel Cero, Mar del Plata 7600, Argentina.

Tropical medicine and infectious disease

|October 27, 2023

概括

复星 (Rsv) 在体外表现出抗球菌活性,但在体内无效. 这种药物是药物,是药物.

科学领域:

寄生虫学的寄生虫学
药理学药理学是指药理学的学科.
免疫学免疫学免疫学

背景情况:

脊髓灰质炎 (Echinococcosis) 是一个重大的全球卫生挑战.
需要新的治疗药物来对抗球菌病.
复星 (Rsv) 是一种天然的多,具有潜在的药用特性.

研究的目的:

为了评估白醇对 Echinococcus granulosus 和 Echinococcus multilocularis 幼虫阶段的疗效.
研究Rsv对球菌病的体外和体内影响.
评估Rsv对宿主免疫细胞的影响,特别是骨髓造血干细胞 (HSC) 和树突细胞 (BMDC).

主要方法:

在体外测定:光学/电子显微镜,RT-qPCR,免疫组织化学.
在体内研究:囊性 (CE) 和气泡状球菌 (AE) 的小鼠模型.
流细胞计和RT-qPCR用于分析HSC和BMDC种群和功能.

主要成果:

在体外,RSv降低了寄生虫的生存能力,并造成了超结构性损伤,提高了自和降低了TOR通路的调节.
在体内,Rsv的使用是无效的,并且在CE和AE模型中促进了寄生虫的发展.
在AE模型中的RSV治疗导致HSC扩张和分化为抗炎BMDCs.

结论:

复星在体外表现出抗球菌的作用,但在体内未能证明有效性.
无效的潜在原因包括低囊内药物度和抑制作用.
Rsv具有免疫调节特性,影响HSC和BMDC,这可能会抵消其直接的抗寄生虫作用.

关键词:

自自是自的过程.树突细胞分化树突细胞分化埃奇诺科科菌病 (echinococcosis) 是一种造血干细胞扩张造血干细胞扩张复星醇是一种复星醇.

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