矿业环境中的微核,农药和元素混合物:的防作用
Marcela E Varona-Uribe1, Sonia M Díaz1, Ruth-Marien Palma2
1School of Medicine and Health Sciences, Universidad del Rosario, Bogotá D.C. 111221, Colombia.
Toxics
|October 27, 2023
概括
哥伦比亚的采矿地区显示出不同的化学物质暴露和类似的微核频率. 具有抑制作用,在低剂量时起化剂的作用,但在高剂量时可能增加毒性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人类健康风险评估
背景情况:
- 由于哥伦比亚的化学混合物污染,采矿和农业活动是人类健康风险的重要来源.
- 之前的研究还没有完全阐明各种污染物的复杂相互作用及其在这些地区对健康的影响.
研究的目的:
- 探索微核频率,农药暴露和哥伦比亚采矿地区的基本体力负担之间的联系.
- 研究作为化剂的潜在作用及其与有毒元素的相互作用.
主要方法:
- 对来自铁,黄金和矿区的247人进行横截面研究.
- 在血液和尿液中分析农药,在头发中量化68个元素,在淋巴细胞中分析微核.
- 统计分析包括主要组件分析和Poisson回归来探索关联和相互作用.
主要成果:
- 在活跃的采矿场地发现了最高元素度,而铁矿显示出最有毒的混合物.
- 杀虫剂检测率一般较低,除了特定地点的甲基和乙基.
- 在采矿环境中,微核的频率是相似的,显示出一种抑制作用,在低剂量时起着化剂的作用,在高剂量时可能增强毒性.
结论:
- 作为保护剂或毒性增强剂的双重作用取决于其度和区域适应性.
- 农药和元素暴露的多样性凸显了对特定区域的风险评估的需要.
- 了解的抑制作用对于管理受污染的采矿环境中的健康风险至关重要.
更多相关视频
08:46Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
Published on: April 21, 2022
2.4K
06:00Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy
Published on: May 27, 2022
2.6K
相关概念视频
01:27The Periodic Table and Organismal Elements
17.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
17.1K
01:25Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K