生殖年龄妇女暴露于多种金属及其与无法解释的反复流产的关联
Yingying Zhang1, Xi Yan1, Jianhua Tan2
1Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510632, China.
Toxics
|October 27, 2023
概括
接触重金属会影响女性的生殖能力. 这项研究发现,在没有复发性流产的妇女中,和的水平较高,和的水平较低,与未解释的复发性流产 (uRM) 的妇女相比.
科学领域:
- 生殖毒理学 生殖毒理学
- 环境健康 环境健康
- 临床化学 临床化学
背景情况:
- 暴露于重金属是女性生殖结果和胚胎发育不良的已知危险因素.
- 无法解释的反复流产 (uRM) 影响了很大一部分女性,其根本原因往往仍然难以捉摸.
- 了解环境因素的作用,如金属暴露,对于识别RM的潜在贡献者至关重要.
研究的目的:
- 调查多种金属暴露与不明原因的反复流产 (uRM) 之间的关联.
- 为了检查不同金属暴露在有或没有反复流产史的妇女之间的相关性.
- 识别可能与RRM风险相关的特定金属元素.
主要方法:
- 来自275名参与者的血清样本 (43个对照组,232个RMR病例) 用诱导合等离子体质谱学分析了22个元素.
- 参与者根据流产次数 (2M,3M,≥4M) 分为对照组,RM和子组.
- 进行了统计分析,包括对年龄,BMI和教育进行调整,以评估金属含量和流产风险之间的关联.
主要成果:
- 与RMR总组和所有RMR亚组相比,对照组观察到较高的血清和水平.
- 与RMR总组及其子组相比,对照组发现了较低的和血清水平.
- 经过调整后的分析显示,和暴露与流产风险之间存在负相关性,而暴露则显示出正相关性.
结论:
- 血清中,,和的含量在有或没有不明原因的反复流产的女性之间有所不同.
- 和暴露似乎可以防止流产,而暴露与风险增加有关.
- 这些发现表明,血液中特定金属元素水平的变化可能会导致无法解释的反复流产的风险.
相关概念视频
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
The Periodic Table and Organismal Elements
17.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
17.1K
Disorders of the Female Reproductive System
375
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
375
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Spermatogenesis
102.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.6K
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K


