调节多环芳的心血管作用:身体炼作为一种保护策略
Gabriel A Rojas1,2,3, Nicolás Saavedra1, Cristian Morales1,2,4
1Center of Molecular Biology & Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile.
运动可以抵消空气污染引起的心血管风险. 这项研究表明,运动有助于减少由多环芳 (PAHs) 引起的炎症和内皮功能障碍.
科学领域:
- 环境健康 环境健康
- 心血管生理学心血管生理学
- 运动科学 运动科学
背景情况:
- 空气污染,特别是多环芳 (PAHs),增加了心血管疾病的风险.
- 运动是已知的心血管风险减轻剂,但其对污染引起的伤害的有效性尚未得到充分证实.
研究的目的:
- 在小鼠模型中研究有氧运动对炎症,内皮功能障碍和因PAH暴露引起的REDOX失衡的保护作用.
主要方法:
- 雄性BALB/c小鼠被暴露在一种PAH混合物 (,,烯) 中.
- 小鼠接受了有氧运动训练,同时暴露于PAH.
- 评估了血清细胞因子,大动脉组织基因表达 (炎症,内皮功能障碍,REDOX) 和ICAM-1/VCAM-1蛋白水平.
主要成果:
- 运动调节了血清炎症性细胞因子水平.
- 有氧运动改变了与内皮功能障碍和大动脉组织中REDOX不平衡相关的基因表达.
- 运动影响了ICAM-1和VCAM-1的蛋白质表达.
结论:
- 运动显示有潜力减轻PAH引起的心血管损伤.
- 空气运动可以作为对空气污染暴露,特别是PAHs对心血管的不利影响的对策.
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