在健康风险评估中应用生理学基础的毒动力学模型
Mengting Chen1, Ruihu Du2, Tao Zhang2
1Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, China.
Toxics
|October 27, 2023
概括
与较旧的方法相比,生理学性毒动力学 (PBTK) 模型提供了更优质的化学物质在体内分布的定量分析. 这些先进的毒动力学模型提高了对异生菌的健康风险评估.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 药理动力学 药理动力学
背景情况:
- 毒动力学对于评估外来化学物质 (异生菌) 给健康带来的风险至关重要.
- 传统的隔间模型在确定特定器官内的化学度以及跨物种或暴露途径的数据推断方面存在局限性.
- 这些局限性阻碍了对健康风险的准确评估和有效的管理策略.
研究的目的:
- 审查在健康风险评估中开发和应用基于生理学的毒动力学 (PBTK) 模型.
- 分析当前PBTK模型的局限性.
- 在毒理学中讨论PBTK建模的未来前景.
主要方法:
- 对生理学基础毒动力学 (PBTK) 模型的现有文献的审查.
- 对PBTK模型构建的分析,包括生理参数.
- 对PBTK模型应用在量化描述化学物质吸收,分布,新陈代谢和分泌 (ADME) 的评估.
主要成果:
- PBTK模型提供了化学ADME在各种暴露途径和剂量上的定量描述.
- PBTK模型建立了化学物质暴露和毒性影响之间的相关性.
- PBTK 模型在风险评估的跨种类和间路线推断中显示出实用性.
结论:
- 基于生理学的毒动力学 (PBTK) 模型是对外源生物的定量健康风险评估和管理的强大工具.
- PBTK模型克服了经典模型的局限性,使得更好的推断和目标器官分析成为可能.
- 进一步开发和应用PBTK模型对于推动毒理学科学和公共卫生保护至关重要.
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