对REV-ERBα选择性激动剂SR-29065 (34) 对自身免疫性疾病的结构-活性关系和生物研究

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Yuanjun He1, Di Zhu1, Kevin Greenman2

  • 1The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida 33458, United States.

Journal of medicinal chemistry
|October 27, 2023
PubMed
概括

研究人员开发了一种针对REV-ERBα的新型化合物,用于治疗自身免疫性疾病. 这种化合物在小鼠模型中降低了T助手17 (TH17) 细胞活性,显示出新疗法的潜力.

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