宿主细胞几何和细胞骨组织规范 - - 宿主细胞在纳米尺度上的相互作用
Easter Ndlovu1, Lucas Malpartida2, Taranum Sultana1
1Department of Chemistry and Biochemistry, University of Regina, 3737 Wascana Parkway, Regina S4S 0A2, Saskatchewan, Canada.
ACS applied materials & interfaces
|October 27, 2023
概括
坎迪达真菌比健康细胞更强烈地粘附于癌细胞. 这种增加的粘附性与癌细胞有关.
科学领域:
- 菌类学 菌类学是指菌类学.
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- * * 候选菌种是机会性真菌病原体,会引起候选病,特别是在免疫受损的个体中.
- * 宿主细胞粘附对于 * 候选虫 * 病原和寄生虫生存至关重要.
- * 癌细胞表现出不同的机械性质 (粘性,粘性弹性),影响入侵和迁移.
研究的目的:
- * 调查 * 坎迪达 * 和癌症和非癌症人类细胞系之间的粘附机制.
- *为了将宿主细胞的机械生物学特性与 *Candida* 粘附度相关联.
- * 探索细胞骨组织在宿主-病原体相互作用中的作用.
主要方法:
- * 原子力显微镜 (AFM) 在单细胞力光谱模式下.
- * 探测 * 坎迪达 * 种类和人类细胞系 (癌症与非癌症) 之间的相互作用力.
主要成果:
- * 观察到Candida和人类细胞之间存在显著的粘附.
- *与非癌细胞相比,Candida和癌细胞系之间发生了较大的粘附.
- *增强的粘附与癌细胞无组织的细胞骨架和降低的刚性相关.
结论:
- * *Candida*粘附受宿主细胞机械生物学特性显著影响.
- * 癌细胞的改变机械特性,包括细胞骨的破坏,促进增强的真菌粘附.
- * 操纵宿主细胞的机械性质为 кандидоз提供了潜在的治疗途径.
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