在非细胞毒性和免疫疗法药物治疗后的丸功能
David J Handelsman1,2, Amanda Idan1, Sue Sleiman1
1Andrology Department and Clinical Andrology Laboratory, Concord Hospital, Sydney, New South Wales, Australia.
Andrology
|October 27, 2023
概括
新型癌症药物,如非细胞毒性和免疫疗法治疗适度影响精子生产和相关激素,对接受治疗的男性水平的影响最小.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺乏对新型非细胞毒性药物和免疫治疗药物对人类丸功能影响的系统研究.
- 了解这些影响对于管理癌症患者的生殖健康至关重要.
研究的目的:
- 研究非细胞毒性和免疫治疗药物对丸外分泌和内分泌功能的影响.
- 为了在癌症患者中描述这些影响,这些癌症患者以前没有接触过淋巴细胞毒性疗法.
主要方法:
- 一项混合纵向和横截面研究,涉及34名接受非细胞毒性和免疫治疗药物治疗的男性.
- 用数据建模来评估随着时间的推移丸功能的变化.
- 在治疗前和治疗期间收集精液和血液样本,并进行长期随访.
主要成果:
- 观察到精子产量和精子度减少了50%左右.
- 血清毛囊刺激激素增加,而血清抑制素B降低.
- 丸激素,黄蛋白化激素和性激素结合型全球蛋白水平没有受到影响.
结论:
- 非细胞毒性和免疫治疗药物对丸外分泌功能及其荷尔蒙调节 (FSH,inhibin B) 产生适度的影响.
- 这些治疗对丸内分泌功能,特别是丸激素和LH水平的影响最小.
- 需要进一步研究更大的样本大小和更长的随访时间.
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