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Updated: Jul 12, 2025

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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Published on: February 7, 2019

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高通量数据和建模揭示了转录因子蛋白合作性DNA结合机制的洞察力

Vincentius Martin1,2, Farica Zhuang1,2, Yuning Zhang2,3

  • 1Department of Computer Science, Durham, NC 27708, USA.

Nucleic acids research
|October 27, 2023
PubMed
概括

了解合作转录因子 (TF) 结合是基因调节的关键. 本研究开发了一种使用DNA库和机器学习准确建模TF合作性的新方法,揭示关键序列和空间因素.

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