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PKCδ通过SIRT6调节染色体重塑和DNA修复.

Trisiani Affandi1, Ami Haas1, Angela M Ohm1

  • 1Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Molecular cancer research : MCR
|October 27, 2023
PubMed
概括

蛋白激酶C三角酶 (PKCδ) 通过通过Sirtuin 6 (SIRT6) 控制染色质可访问性和基因素修饰来调节DNA修复和对辐射的敏感性. 抑制PKCδ增强了DNA修复,提供了潜在的辐射保护策略.

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