新生多细胞生命周期的进化后果
Jennifer T Pentz1, Kathryn MacGillivray2,3, James G DuBose2
1Los Alamos National Laboratory, Los Alamos, United States.
eLife
|October 27, 2023
概括
在酵母中研究了进化过渡到多细胞性. 克隆雪花酵母与聚合群群酵母相比,进化了更大的群体水平适应性,突出了生命周期对多细胞性的影响.
科学领域:
- 进化生物学是进化的生物学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 过渡到多细胞化需要群体作为适应性个体.
- 假设克隆发育有助于这一过渡,但缺乏经验测试.
- 酵母模型提供了一个研究多细胞性进化的系统.
研究的目的:
- 实验测试克隆发育在多细胞性进化的作用.
- 为了比较克隆和聚合酵母生命周期之间的进化动态.
- 为了研究早期多细胞进化中的选择水平 (细胞与组).
主要方法:
- 雪花酵母 (克隆性) 和花酵母 (聚合性) 的复制种群的演变.
- 实施日常选择以实现快速生长 (细胞分裂) 和快速沉积 (组大小).
- 利用基因组测序和数学建模来分析进化变化.
主要成果:
- 这两种酵母类型都适应了,显示出增长和生存的增加.
- 雪花酵母主要通过改善群体级特征 (群体生存) 获得了健身.
- 酵母主要通过增加细胞生长来获得健康,这表明细胞水平的选择.
结论:
- 克隆生命周期在群体层面促进了达尔文主义个性的演变.
- 早期的多细胞生命周期极大地影响了适应的轨迹.
- 基因漂移,由克隆瓶放大,对多细胞进化有复杂的影响.
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