分析移植接受者对COVID-19疫苗的反应
Tanusya Murali Murali1,2, Bhuvaneshwari Shunmuganathan1,3, Emma Li-Lin Trueman1
1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
ImmunoHorizons
|October 27, 2023
概括
在移植接受者中,COVID-19疫苗接种反应减少. 瑞-生物科技疫苗的三个剂量显示,针对SARS-CoV-2变种的中和抗体标位较低,特别是Omicron.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 移植 移植 移植 移植
背景情况:
- 在健康人群中,COVID-19疫苗显著降低了疾病的严重程度.
- 在免疫抑制的移植接受者 (RTRs) 中对COVID-19疫苗的免疫反应尚不清楚.
- 新出现的SARS-CoV-2令人担忧的变种 (VOCs) 可能会进一步降低疫苗的有效性.
研究的目的:
- 在RTRs中分析用Pfizer-BioNTech疫苗三剂接种后对SARS-CoV-2VOCs的中和抗体反应.
- 将RTRs中的疫苗诱导免疫反应与健康对照进行比较.
- 确定影响RTRs疫苗反应的因素.
主要方法:
- 对中和抗体反应的纵向分析.
- 这项研究包括129名接受脏移植的接受者,他们接受了瑞-生物科技疫苗 (BNT162b2) 的三剂.
- 伪病毒中和试验被用来评估对野生型和VOC的抗体标位,包括Omicron BA1和BA2.
主要成果:
- 只有51.9%的RTRs具有可测量的IgG反应,41.1%具有显著的中和抗体标位 (>50%).
- 抗体结合对武汉-胡-1和三角洲变种最强,对欧米克朗BA1或BA2没有可检测的中和.
- 高龄和酸治疗与疫苗诱导的免疫反应减少有关.
结论:
- 脏移植接受者对瑞-生物科技COVID-19疫苗的血清反应减弱.
- 在这种人群中,疫苗对Omicron变种的有效性显著降低.
- 年龄和特定的免疫抑制疗法影响RTR的疫苗免疫性,需要定制的监测和管理策略.
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