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遗传性听力损失:对潜在治疗和干预措施的系统审查
Yang Lu1, Yuanjia Hu1, Shengyue Wang1
1College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou, China.
American journal of audiology
|October 27, 2023
概括
这一系统性审查强调了基因疗法和耳植入物作为遗传性听力损失的关键治疗方法. 研究正在转向治疗干预,许多研究处于临床验证阶段.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 遗传学 遗传学 是一个
- 听力学 听力学是指听力学.
背景情况:
- 遗传性听力损失影响着大量人群,需要有效的治疗策略.
- 目前的研究重点是从预防措施过渡到先进的治疗干预措施.
- 了解研究环境对于指导未来治疗开发至关重要.
研究的目的:
- 系统地审查关于遗传性听力损失的治疗方法和干预措施的现有文献.
- 制定药物和基因疗法的临床应用指南.
- 确定遗传性听力损失治疗的未来研究方向.
主要方法:
- 在PubMed和Web of Science数据库中的系统文献搜索.
- 使用R语言,VOSviewer和CiteSpace进行图书统计分析,用于数据可视化.
- 按照PRISMA指南进行数据聚类和描述性分析.
主要成果:
- 确定了103篇研究文章,平均年度出版物增长率为12.73%.
- 美国在出版物和引用方面处于领先地位;80%的出版物得到了资助.
- 关键的研究领域包括耳植入物和基因疗法,59.22%的干预措施在临床验证中.
结论:
- 遗传性听力损失的研究正在转向治疗方法.
- 基因向干预显示出作为有效治疗方法的重大前景.
- 进一步的研究和临床验证对于推进治疗选择至关重要.
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