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在老兵人口中,耳突触和耳的生理相关性之间的关联

Naomi F Bramhall^1,2, Sarah M Theodoroff^1,2, Garnett P McMillan¹

¹VA RR&D National Center for Rehabilitative Auditory Research, Veterans Affairs Portland Health Care System, OR.

Journal of speech, language, and hearing research : JSLHR

|October 27, 2023

概括

退伍军人的噪音诱发的耳声可能与耳突触症有关,这是一种导致突触损失的疾病. 这项研究发现,退伍军人患有耳有生理学证据表明有突触,类似于20年的衰老.

科学领域:

听觉神经科学听觉神经科学
耳鼻喉科耳鼻喉科耳鼻喉科
退伍军人健康退伍军人的健康

背景情况:

暴露于噪音是耳突触病的已知危险因素,这种情况可能导致耳声.
退伍军人经常经历高噪音暴露,导致 tinnitus 在这个人群中的高患病率.
耳突触,虽然很难在人类中直接评估,但在动物模型中可以观察到生理相关性.

研究的目的:

调查退伍军人的耳与耳突触病的生理标志物之间的关联.
为了确定听觉脑干反应 (ABR),中耳肌反射 (MEMR) 和信封后反应 (EFR) 是否在有耳的退伍军人中减少.

主要方法:

参与者被分为三组:有耳的退伍军人,没有耳的退伍军人和非退伍军人对照,所有人都有正常的听力图.
用贝叶斯回归分析来建模退伍军人身份和耳对ABR,MEMR和EFR测量的影响.
该研究将退伍军人耳的EFR减少与先前研究中观察到的与年龄相关的变化进行了比较.

主要成果:

与非退伍军人相比,患有耳的退伍军人表现出较低的MEMR和EFR大小.
在EFR大小中观察到的最显著的减少.
在退伍军人中观察到的EFR大小/突触计数的减少与大约20年的与年龄相关的衰退相当.

结论:

耳突触是噪音暴露退伍军人的耳感知的一个可能的贡献者.
像EFR这样的生理测量可以作为人类研究中突触病的指标.
这些发现突出了退伍军人耳的潜在机制,并建议未来研究和干预的途径.

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