在英国生物银行队列中对睡眠时间,失眠和大脑结构的综合评估
Aleks Stolicyn1, Laura M Lyall2, Donald M Lyall2
1Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sleep
|October 27, 2023
概括
睡眠时间长于建议时间与较差的大脑健康指标有关,包括灰色和白质量减少. 较短的睡眠与较低的皮质表面区域有关. 失眠与灰色和白质量增加有关.
科学领域:
- 神经成像是一种神经成像.
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 充足的睡眠时间对整体健康至关重要.
- 国家睡眠基金会 (NSF) 的指导方针建议成人每晚睡眠7-9小时.
- 偏离推睡眠时间对大脑结构的影响尚未完全理解.
研究的目的:
- 调查睡眠时间 (比NSF建议更长或更短) 和失眠与大脑结构之间的关联.
- 探索这些睡眠模式如何与大脑形态学,白质微观结构和大脑年龄有关.
主要方法:
- 分析了来自9000-32,000名参与者 (44-82岁) 的英国生物库数据.
- 评估自我报告的睡眠时间遵守NSF指南和自我报告的失眠.
- 评估大脑结构测量,包括皮层/皮下形态测量,白质微观结构,大脑年龄差距和白质病变.
主要成果:
- 较长的睡眠时间与较低的灰色/白质体积相关,皮质厚度降低,大脑年龄差距更大,白质病变增加,海马体积更低.
- 较短的睡眠时间与较高的白质量和较低的皮质表面积有关.
- 失眠与较高的灰色/白质体积和桃体,海马体和膜体积的增加有关.
结论:
- 睡眠时间长于建议时间与大脑结构的广泛差异有关,这表明对大脑健康的潜在负面影响.
- 睡眠时间少于建议显然与皮质表面积的减少有关.
- 需要进一步的研究来了解这些机制,并将长时间的睡眠时间视为潜在的大脑健康标志物.
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