相关实验视频

Updated: Jul 12, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

同时发生甲状腺自身免疫性疾病和甲状腺癌的临床和分子影响:从长椅到床边

Victor Alexandre Dos Santos Valsecchi^1,2, Felipe Rodrigues Betoni^1,2, Laura Sterian Ward³

¹Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Federal University of São Paulo, São Paulo, Brazil.

Reviews in endocrine & metabolic disorders

|October 27, 2023

概括

甲状腺自身免疫和甲状腺癌具有相似的分子路径,特别是PD-1/PD-L1轴. 了解这种联系可能会改善个性化癌症治疗策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

免疫检查点抑制剂 (PD-1,CTLA-4) 在癌症治疗中至关重要,突出了免疫,自身免疫和癌症之间的相互作用.
自免疫性甲状腺疾病和甲状腺癌是常见的,PD-1/PD-L1轴在两者都起作用.

研究的目的:

探索甲状腺自身免疫和甲状腺癌之间的分子联系.
研究甲状腺自身免疫在甲状腺癌管理中的共享分子特征和潜在的预后影响.

主要方法:

关于免疫检查点抑制剂,PD-1/PD-L1轴,自身免疫性甲状腺疾病和甲状腺癌的当前文献的综述.
在这两种条件下分析分子病理和免疫逃生机制.

主要成果:

PD-1/PD-L1轴与自身免疫性甲状腺疾病 (甲状腺功能低下症) 和甲状腺癌的病原发生有关.
甲状腺自身免疫可能与较不激进的甲状腺癌呈现有关,尽管分子机制需要进一步阐明.

结论:

甲状腺自身免疫和甲状腺癌可能有共同的分子基础,这表明它们是相关的疾病.
需要进一步的研究来澄清甲状腺自身免疫对甲状腺癌的分子联系和预后影响,以帮助个性化患者管理.

关键词:

自免疫性甲状腺疾病.免疫微观环境免疫微观环境免疫耐受性是一种免疫耐受性.乳头甲状腺癌是一种乳头甲状腺癌.瘤的免疫逃逸是瘤的免疫逃逸.

更多相关视频

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...