毒性,AS3MT基因多态性和2型糖尿病发病之间的关联
Saima Shokat1, Riffat Iqbal2, Samreen Riaz3
1Department of Zoology, Government College University, Lahore, Pakistan. saimashokat@gcu.edu.pk.
Biological trace element research
|October 27, 2023
概括
饮用水中的 (As) 暴露与2型糖尿病 (T2D) 有关. 在AS3MT基因中的特定基因变异 (rs11191439) 显示出与巴基斯坦污染地区T2D发展的显著关联.
科学领域:
- 环境健康 环境健康
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 饮用水中的 (As) 污染是全球公共卫生问题.
- AS3MT基因在代谢中起着至关重要的作用.
- 在AS3MT中的遗传变异,特别是单核酸多态 (SNP),可能会影响对引起的疾病的易感性,如2型糖尿病 (T2D).
研究的目的:
- 调查AS3MT基因,特别是rs11191439多态,与巴基斯坦旁遮普邦高水平暴露的人群中T2D发病率之间的关联.
- 量化饮用水中的含量,参与者的尿液和血液样本.
主要方法:
- 一项涉及200名来自巴基斯坦拉合尔和卡苏尔暴露地区的参与者的病例控制研究.
- 进行了基因型鉴定,以分析AS3MT基因中的rs11191439多态性.
- 测量了饮用水,尿液和血液样本中的含量.
主要成果:
- 研究区域的饮用水含量显著增加 (115.54±1.23μg/L和96.88±0.48μg/L).
- 与非糖尿病患者相比,糖尿病患者在尿液中的度较高.
- 在T2D患者和对照患者 (P <0.05) 之间观察到AS3MT rs11191439 (T/C) 多态的等位基因频率和基因型分布的显著差异.
结论:
- AS3MT基因,特别是rs11191439多态,在居住在污染地区的人群中与2型糖尿病有显著的关联.
- 这些发现突出了遗传易感性在相关的T2D发展中的作用,并强调了暴露的公共健康风险.
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