从中年到老年,表观遗传衰老和脆弱的时间动力学
Jonathan K L Mak1, Ida K Karlsson1, Bowen Tang1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
概括
衰老时钟 (DunedinPACE) 的变化预测了未来的脆弱性,这表明它可能是生理衰退的早期指标. 其他表观遗传时钟没有显示出这种与随时间变弱的动态联系.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老的生物标志物
背景情况:
- 表观遗传钟和脆弱指数 (FI) 是已知的生物衰老指标.
- 这些衰老标志物之间跨时间年龄的动态关系尚未得到充分理解.
研究的目的:
- 调查多个表观遗传钟与老年人脆弱指数之间的双向,纵向关联.
- 为了确定表观遗传衰老是否预测随后的脆弱性或反之.
主要方法:
- 分析了来自524名 (50-90岁) 个体的1,309个重复测量结果,这些数据来自瑞典采养/老龄化双胞胎研究.
- 使用了五个表观遗传时钟 (PCHorvathAge,PCHannumAge,PCPhenoAge,PCGrimAge,DunedinPACE) 和一个42项脆弱指数 (FI).
- 采用双变化得分模型来评估随时间推移的动态关联.
主要成果:
- 脆弱指数显示随着年龄的增长而加速,非线性增加,而大多数表观遗传时钟则线性增加.
- 基于四个主要成分的表观遗传时钟 (PCHorvathAge,PCHannumAge,PCPhenoAge,PCGrimAge) 显示了与FI的截面关联,但没有动态纵向联系.
- 宁PACE显示出单向的关联:较高的宁PACE预测了FI的随后增加,但不是相反.
结论:
- 在表观遗传衰老和脆弱之间存在一个时间顺序,DunedinPACE的变化先于FI的变化.
- DUNEDINPACE可以作为系统生理衰退的早期预测标志物.
- 这一发现推动了我们对表观遗传调节和身体衰老轨迹之间的相互作用的理解.
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