丸激素替代疗法在纠正低阴性男性贫血的有效性:一个随机临床试验
Karol M Pencina1, Thomas G Travison2, Andrew S Artz3
1Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
JAMA network open
|October 27, 2023
概括
替代疗法 (TRT) 有效地纠正了腺癌男性的贫血. 此外,TRT还降低了无贫血男性的贫血发病率,改善了血红蛋白水平.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 临床试验 临床试验
背景情况:
- 缺乏症 (阴性双胞胎缺陷症) 与轻度贫血有关.
- 替代疗法 (TRT) 在治疗低腺男性贫血的有效性尚未完全理解.
研究的目的:
- 为了评估TRT在纠正男性患有阴道腺缩和贫血的贫血方面的有效性.
- 评估TRT在没有贫血的阴阴腺男性中预防贫血发展中的作用.
主要方法:
- 在TRAVERSE研究中进行的一项随机,安慰剂对照试验.
- 包括5204名年龄在45-80岁的男性,患有阴性腺体缺陷症和心血管疾病或心血管疾病风险.
- 参与者每天接受1.62%的丸激素凝或安慰剂凝.
主要成果:
- 在多个时间点 (P=.002) 中,TRT接受者与安慰剂相比,贫血的比例显著增加.
- 与安慰剂组相比,接受TRT的男性患贫血的人较少.
- 血红蛋白的变化与能量水平的改善相关.
结论:
- 在中年和老年男性中,TRT在纠正贫血方面比安慰剂更有效.
- 在最初没有贫血的男性中,TRT可以减少贫血的发生率.
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