时间限制饮食对2型糖尿病成年人减肥的影响:一项随机临床试验
Vasiliki Pavlou1, Sofia Cienfuegos1, Shuhao Lin1
1Department of Kinesiology and Nutrition, University of Illinois Chicago.
与卡路里限制相比,时间限制饮食 (TRE) 在2型糖尿病 (T2D) 的成年人中有效降低体重和改善血糖控制. 需要进一步的研究,以在更大的试验中证实这些发现.
科学领域:
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
- 饮食干预 饮食干预
背景情况:
- 时间限制饮食 (TRE) 是一种流行的饮食方法.
- 在2型糖尿病 (T2D) 中评估TRE的长期随机临床试验有限.
- 了解TRE在T2D中的有效性和安全性至关重要.
研究的目的:
- 为了比较TRE与每日卡路里限制 (CR) 的有效性,以及对T2D成年人减肥和血糖控制的对照组.
- 评估TRE对T2D患者代谢风险因素的影响.
主要方法:
- 一个为期6个月的平行组随机临床试验,涉及肥胖和T2D的成年人.
- 参与者被随机分为三个组:8小时TRE,CR (25%的能量限制) 或对照.
- 主要结局是体重的变化;次要结局包括HbA1c水平和代谢风险因素.
主要成果:
- 与对照组相比,TRE显著减少了体重 (-3.56%).
- 与对照组相比,TRE和CR组的HbA1c水平显著降低 (-0.91%和-0.94%,分别).
- 在其他代谢风险因素或组之间的不良事件中没有观察到显著差异.
结论:
- 没有卡路里计数的时间限制饮食 (TRE) 是减肥和改善T2D成年人血糖控制的有效策略.
- 在降低HbA1c水平方面,TRE的疗效与卡路里限制相似.
- 更大的随机临床试验需要更长的随访时间来证实这些发现.
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