在人类成年期,酒精消费和表观遗传年龄加速
Mengyao Wang1, Yi Li1, Meng Lai1
1Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Aging
|October 27, 2023
概括
更高的酒精消费加快了生物衰老,特别是在中年和老年人中. 这种通过表观遗传钟测量的加速衰老,可能解释了酒精.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
- 营养流行病学 营养流行病学
背景情况:
- 酒精消费是一个全球性的健康问题,与衰老有复杂的关联.
- 生物衰老,不同于时间衰老,可以使用表观遗传标记量化.
- 以前的研究还没有完全阐明酒精对成年期生物衰老的影响.
研究的目的:
- 通过基于DNA甲基化的指标,研究酒精消费与生物衰老加速之间的关联.
- 检查表观遗传衰老指标是否调解酒精摄入量与高血压之间的关系.
主要方法:
- 在Framingham心脏研究的3823名参与者 (24-92岁) 上进行了线性回归分析.
- 两种表观遗传衰老指标,GrimAge加速 (GAA) 和PhenoAge加速 (PAA),被用来评估生物年龄加速.
- 在分析中调整了共变量,并对酒精与高血压相关性进行了调解分析.
主要成果:
- 在中年和老年人中,较高的长期平均酒精消耗显著与生物年龄加速 (GAA和PAA) 的增加有关,但在年轻人中并非如此.
- 每天增加一个标准饮料,中年人增加了PAA0.71年,老年人增加了0.60年.
- 在中年参与者中,酒精消费与GAA和PAA的关联比酒和葡萄酒更大.
- 表观遗传衰老指标 (GAA/PAA) 介导了高达28%的酒精消费与高血压之间的关联.
结论:
- 酒精消费与加速的生物衰老有关,这是表观遗传衰老指标表明的.
- 表观遗传加快年龄可能在酒精摄入量与高血压等健康结果之间的关系中起到调解作用.
- 这些发现凸显了酒精在分子水平上对衰老过程的有害影响.
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