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Updated: Jul 12, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

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通过氨基乙醇点击反应合成DNA编码的宏循环

Lijun Fan1, Yang Yu1, Charles Jayne1

  • 1Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Organic letters
|October 27, 2023
PubMed
概括

我们开发了一种新的DNA编码库 (DEL) 兼容的方法,用于创建宏环 (MP). 这种自发的,Cpa和cysteine之间的水性循环反应提供了高产量和广泛适用于药物发现.

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