多功能水凝眼滴用于眼部炎症疾病的协同治疗
Xinyu Liu1, Zhongxing Chen1, Jieyi Bai2
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Key Laboratory of Myopia, Chinese Academy of Medical Sciences; Shanghai Research Center of Ophthalmology and Optometry, Shanghai 200030, China.
ACS nano
|October 27, 2023
概括
新的水凝眼滴结合了甲和基金属有机框架,用于增强紫外线炎治疗. 这种协同方法提高了眼睛的生物可用性,减少了炎症,为眼睛炎症性疾病提供了有前途的治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 尿道炎是一种复杂的眼部炎症疾病,可能导致失明.
- 目前用于前膜炎的皮质类固醇眼滴具有局限性,包括生物可用性差和副作用.
- 需要先进的治疗方法来增强药物输送并更有效地向炎症.
研究的目的:
- 开发多功能水凝眼滴 (DCFH) 用于协同治疗紫外炎.
- 将甲 (DSP) 和基金属有机框架 (Ce-MOF) 纳入热敏水凝 (F127).
- 评估DCFH在改善眼部生物可用性和减少炎症方面的疗效.
主要方法:
- 含有DSP和Ce-MOF的热敏F127水凝眼滴的配方.
- 在体外评估Ce-MOFs和DSP的ROS清除和抗炎活性.
- 在体内评估DCFH在内毒素诱导的脑膜炎小鼠模型中的疗效.
- 对炎症标志物,细胞因子 (TNF-α,IL-6,IL-17),iNOS和NLRP3表达的分析.
主要成果:
- 开发的F127水凝眼滴 (DCFH) 显示出热敏度,厚度和良好的光传导性.
- 在体外,Ce-MOFs增强了DSP的抗炎活性,并降低了活性氧物种 (ROS) 的水平.
- 在体内,DCFH显著减轻了眼部炎症,抑制了关键的炎症性细胞因子,并降低了iNOS和NLRP3的表达.
- 与传统眼滴相比,水凝配方改善了眼部生物可用性.
结论:
- 多功能DCFH水凝眼滴提供了针对紫外炎的协同有效的治疗策略.
- 在热敏水凝中将DSP和ROS清理Ce-MOF结合起来,可以改善治疗结果.
- 这种方法在治疗卵膜炎和其他眼部炎症状况方面呈现出有前途的进展.
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