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左心室辅助器件和全人工心脏的血液相容性和生物物理接口
Angelo Nascimbene1, David Bark2,3, David M Smadja4,5
1Advanced Cardiopulmonary Therapies and Transplantation, University of Texas, Houston, TX.
Blood
|October 27, 2023
概括
像LVAD和TAH这样的机械循环支持 (MCS) 设备可以改善心力衰竭的治疗,但会带来出血和凝血的风险. 本综述比较了长期MCS的这些风险,提供了对血红相容性并发症的见解.
科学领域:
- 心血管医学 心血管医学
- 生物医学工程 生物医学工程
- 血液学 血液学 血液学
背景情况:
- 长期机械循环支持 (MCS) 越来越多地用于心力衰竭,左心室辅助器件 (LVAD) 和全人工心脏 (TAH) 是主要的选择.
- 尽管有临床益处,但MCS与持续的血液相容性并发症有关,包括血栓,出血和脑血管事故.
- 缺乏对LVADs和TAHs之间的并发症的比较分析,考虑到它们不同的血液动力学概况.
结论:
- 这项工作提供了长期LVAD和TAH之间的血液相容性并发症的首次全面比较.
- 了解这些差异对于优化患者管理和设备开发至关重要.
- 进一步研究器件特异性血红相容性是有必要的,以尽量减少不良事件.
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