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性别特定的前额前垂体对行为和应激反应的控制
Derek Schaeuble1, Tyler Wallace1, Sebastian A Pace1
1Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Psychoneuroendocrinology
|October 27, 2023
概括
腹中前额叶皮层 (vmPFC) 到后下丘脑 (PH) 电路在男性和女性中不同调节压力反应. 这一途径减少了男性的同情性压力,但增加了女性的神经内分泌压力.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 生理学 生理学 生理学
背景情况:
- 日常生活中的压力加剧了抑郁症和心血管疾病.
- 将心理压力与生理结果联系起来的生物机制尚不清楚.
- 腹中前额叶皮层 (vmPFC) 以性别特定的方式影响行为和生理学.
研究的目的:
- 为了研究腹中前额叶皮层 (vmPFC) 向后下丘脑 (PH) 的投射是否调节压力反应.
- 确定vmPFC-PH电路在行为和生理压力中的性别特异性作用.
主要方法:
- 在雄性和雌性大鼠中对vmPFC-PH电路的光遗传刺激.
- 评估社会和动机行为.
- 测量生理应激反应 (交感和神经内分泌).
- 在vmPFC-PH神经元中,交叉基因方法对 synaptobrevin 进行敲击.
主要成果:
- 在男性中,vmPFC-PH电路刺激促进了积极的动机价值,并减少了同情应激反应.
- 在男性中,vmPFC-PH电路对于这些效应是充足的,也是必要的.
- 在女性中,vmPFC-PH电路没有影响社会或偏好行为.
- 在女性中,vmPFC-PH电路足够且必要地提高神经内分泌应激反应.
结论:
- 皮层对应激反应和行为的调节部分是由向下丘脑的投射介导的.
- vmPFC-PH电路在调节压力反应方面发挥着性别特异性的作用.
- 这些发现揭示了压力适应性性别差异的神经电路基础.
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