从患有TP53突变的AML患者的PBMC中生成iPS细胞系 (SYSUSHi002-A) 并对其进行表征
Lihua Yuan1, Yaqun Wang2, Rongli Xie2
1Pediatric Purgery Department, The University of Hong Kong Shenzhen Hospital, Shenzhen, Guangdong Province 518000, China.
Stem cell research
|October 27, 2023
概括
研究人员从急性髓性白血病 (AML) 细胞创建了一种新型诱导多能干细胞 (iPSC) 系. 这个iPSC系携带TP53突变,可以分化为多种细胞类型.
科学领域:
- 干细胞生物学 干细胞生物学
- 癌症研究 癌症研究
- 遗传学 是一个遗传学.
背景情况:
- 急性髓性白血病 (AML) 是一种异质性癌症.
- TP53基因突变在AML中很常见,并且与预后不佳有关.
- 诱导多能干细胞 (iPSCs) 为疾病建模提供了宝贵的工具.
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