实验TiF4/NaF溶液对防止牙侵蚀的影响
Mariele Vertuan1, Júlia França da Silva1, Beatriz Martines de Souza1
1Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
Archives of oral biology
|October 27, 2023
概括
四化物/化物 (TiF4/NaF) 口水有效地保护牙面膜免受酸性侵蚀,性能与商业化物冲洗相美. 参与者发现TiF4/NaF溶液可以接受,副作用最小.
科学领域:
- 牙科研究 牙科研究
- 材料科学 材料科学 材料科学
- 生物化学 生化学
背景情况:
- 牙侵蚀是一个越来越令人担忧的问题,导致牙面膜去矿化.
- 化物化合物被广泛用于预防牙腐烂和侵蚀.
- 新的化物配方正在不断开发,以加强保护.
研究的目的:
- 评估四化物/化物 (TiF4/NaF) 溶液对牙侵蚀的体内保护作用.
- 为了比较TiF4/NaF与商业氨基化物/石墨化物 (AmF/NaF/SnCl2) 口水和安慰剂的疗效.
- 评估参与者对实验TiF4/NaF溶液的感知和接受度.
主要方法:
- 一项随机,双盲,安慰剂控制的体内研究,涉及33名参与者.
- 参与者用TiF4/NaF,AmF/NaF/SnCl2或水 (安慰剂) 冲洗.
- 使用1%的酸诱导了乳去矿化,并使用阿塞纳佐色度法测量了离子 (Ca2+) 释放.
主要成果:
- 与安慰剂相比,TiF4/NaF和AmF/NaF/SnCl2溶液都显著减少了的释放 (p < 0.0006).
- 在TiF4/NaF和AmF/NaF/SnCl2组之间,Ca2+释放的减少是可比的 (p = 0.99).
- TiF4/NaF表现出良好的可接受性,只有一个参与者报告了不愉快的味道,一个参与者报告了轻微的灼热感.
结论:
- 实验性TiF4/NaF溶液在保护牙免受侵蚀性去矿化方面表现出与商业AmF/NaF/SnCl2口水相提并论的疗效.
- TiF4/NaF在参与者中表现出良好的可接受性,这表明其作为有效的抗侵蚀剂的潜力.
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