胰岛素样生长因子结合蛋白-2与胰岛素敏感性,甲胺和T2D患者的死亡率之间的关联
Rikke Hjortebjerg1, Maja R Kristiansen2, Ivan Brandslund3
1Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Denmark; Endocrine Research Unit, Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, Denmark.
Diabetes research and clinical practice
|October 27, 2023
概括
在2型糖尿病中,高胰岛素样生长因子结合蛋白-2 (IGFBP-2) 与胰岛素分泌量降低和死亡风险增加有关. 在这项研究中,甲胺治疗没有影响IGFBP-2水平.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物标志物 生物标志物
背景情况:
- 血清胰岛素样生长因子结合蛋白-2 (IGFBP-2) 在2型糖尿病 (T2D) 中通常较低.
- 一种常见的T2D药物梅特福林可能会影响IGFBP-2水平.
- 矛盾的是,高的IGFBP-2与T2D患者的死亡率增加相关.
研究的目的:
- 调查IGFBP-2水平,甲福林治疗和T2D中的胰岛素敏感性标志物之间的关系.
- 评估IGFBP-2与先前存在的并发症的关联.
- 确定IGFBP-2在五年随访期内对死亡率的预测值.
主要方法:
- 该研究分析了来自859名未接受治疗和558名接受甲福林治疗的2型糖尿病患者的血清样本.
- 参与者使用国家卫生登记册进行了大约五年的跟踪.
- 在招生时测量IGFBP-2水平,并检查与临床数据和死亡率的关联.
主要成果:
- 在调整年龄后,在甲福林治疗和未经治疗的组之间,IGFBP-2水平类似.
- 较低的IGFBP-2与更高的BMI,禁食葡萄糖和C-水平相关.
- 在注册时患有并发症的患者中观察到更高的IGFBP-2水平,并预测死亡风险增加 (调整后HR:每倍增加2.21).
结论:
- 在T2D中,IGFBP-2与降低葡萄糖和胰岛素分泌有关,不论是否接受了甲福林治疗.
- 升高的IGFBP-2与较高的先前并发症负担有关.
- 高IGFBP-2水平是2型糖尿病患者死亡率的重要预测因素.
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