Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

1.4K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.4K
Solubility Equilibria: Overview01:09

Solubility Equilibria: Overview

694
When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
694
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

209
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
209
Factors Affecting Solubility04:01

Factors Affecting Solubility

33.5K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
33.5K
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

531
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
531
Solubility Equilibria03:07

Solubility Equilibria

52.7K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
52.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

From simplicity to complexity: how excipients shape stability and disintegration of immediate-release tablets.

International journal of pharmaceutics·2026
Same author

Identification of tuna species used by the Portuguese canning industry through a DNA-based approach.

Scientific reports·2025
Same author

Pituitary Apoplexy: An Uncommon Cause of Postpartum Headache.

Cureus·2025
Same author

LC-MS/MS Method Development and Validation for Clinical Pharmacokinetics and Therapeutic Drug Monitoring of Potassium-Competitive Acid Blocker Vonoprazan-Based Triple Therapy for <i>H. pylori</i> in Human Plasma.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Linking powder to tablet stability: Length- and time-scale prediction of moisture sorption.

International journal of pharmaceutics·2025
Same author

Development and Validation of an LC-MS/MS Method for the Simultaneous Determination of Alprazolam, Bromazepam, Clonazepam, Diazepam and Flunitrazpam in Human Urine and Its Application to Samples from Suspected Drug Abusers.

Molecules (Basel, Switzerland)·2025
Same journal

Partition-controlled drug release from polymeric nanocapsules: A physically consistent framework with formulation-specific corrections.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Formulation-dependent differences in systemic glutathione availability: Comparative pharmacokinetics of orally dissolving film and tablet formulations in healthy adults.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Does magnesium permeate the skin? An ex vivo investigation of magnesium ion delivery through intact and barrier-disrupted skin.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Surface engineering of graphene as a novel nano-carrier for doxorubicin using sugar-based deep eutectic systems.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Buprenorphine long acting injectables: clinical needs, pharmacodynamic and pharmacokinetic basis, and design challenges for solid preformed implants.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Design rules for externally triggered drug uncaging under optical and radiolytic regimes.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
查看所有相关文章

相关实验视频

Updated: Jul 12, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
10:20

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

2.6K

在食模拟肠液中结构化溶解性行为.

Maria Inês Silva1, Ibrahim Khadra1, Kate Pyper2

  • 1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|October 27, 2023
PubMed
概括
此摘要是机器生成的。

这项研究评估了模拟肠液中的药物溶解度,发现两种特定介质可以预测大多数药物的最大和最小溶解度. 这为合理的药物开发决策提供了一个新的体外法.

更多相关视频

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.2K

相关实验视频

Last Updated: Jul 12, 2025

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
10:20

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

2.6K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.2K

科学领域:

  • 药理动力学和药物新陈代谢
  • 药物的物理化学药物的物理化学
  • 配方科学科学 配方科学

背景情况:

  • 肠道药物溶解性对于口服药物吸收至关重要.
  • 目前用于测量食状态溶解度的体外方法缺乏关于最佳模拟肠液配方的共识.
  • 在被养的人类肠液中存在显著的组成变异性.

研究的目的:

  • 为了评估24种不同药物的溶解性行为,在9种生物等价的模拟食肠道介质中进行.
  • 为了确定结构化溶解性模式是否存在并与药物的物理化学性质相关.
  • 确定一组最小的介质,可以预测体外药物溶解度范围.

主要方法:

  • 利用了九种生物等价的模拟食肠道介质配方,反映了人类肠道液的变化.
  • 在这些介质中评估了24种药物的溶解性 (酸性,基本性,中性).
  • 根据介质成分 (pH,总两位度) 分类药物溶解性行为.

主要成果:

  • 药物溶解性行为被分为四个不同的组.
  • 对于酸性药物,溶解度主要取决于pH值.
  • 对于弱酸性,基本性和中性药物,溶解度取决于pH值和总两类度 (TAC).
  • 两种特定的介质被确定为能够预测大多数药物的最大和最小溶解度.
  • 四种药物显示出最小的溶解度变化,三种药物表现出不典型的行为.

结论:

  • 在模拟食肠道介质中,在不同的药物类别中显现出结构化的溶解性行为.
  • 使用两个优化的生物等价介质可以有效地预测体外药物溶解度范围.
  • 这种方法与快速状态数据相结合,可以为合理的药物和配方开发提供设计质量决策.
  • 多维介质系统显示出作为一个有希望的体外工具来评估被养的肠道溶解度.