关于Lactobacillus plantarum改善肠道屏障功能在性结肠炎中的机制的进展
Yihui Liu1, Gang Liu1, Jun Fang1
1College of Bioscience and Biotechnology, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Hunan Agricultural University, 1 Nongda Road, Changsha, Hunan 410128, China.
The Journal of nutritional biochemistry
|October 27, 2023
概括
乳植物菌 (L. plantarum) 通过恢复肠道屏障,在治疗性结肠炎 (UC) 中表现有前途. 这种益生菌有助于调节免疫力,减少氧化应激,并改善UC患者的肠道菌群组成.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种影响结肠的慢性炎症性肠病,病因不确定,涉及遗传,环境,微生物和免疫因素.
- 肠道屏障功能障碍,包括机械,化学,免疫和生物学方面,是UC的关键特征.
- 益生菌,有益的肠道细菌,越来越多地被认为是通过增强肠道屏障功能和调节免疫反应,在UC中具有治疗潜力.
研究的目的:
- 审查乳酸菌植物 (L. plantarum) 改善性结肠炎 (UC) 中肠道屏障功能的机制.
- 突出L. plantarum对UC的预防和治疗作用.
主要方法:
- 对研究L. plantarum对UC的影响的文献综述.
- 分析包括免疫反应调节,氧化应激抑制,紧结蛋白表达,粘素生产,肠道微生物群调节和短链脂肪酸 (SCFA) 水平的机制.
主要成果:
- L. plantarum 展示了多种机制来恢复UC的肠道屏障完整性.
- 关键机制包括免疫调节,降低氧化应激,增强紧结蛋白表达,增加粘素生产,改善肠道微生物群和增加SCFA水平.
结论:
- L. plantarum通过加强肠道屏障,为性结肠炎的临床治疗提供了显著的潜力.
- 进一步研究L. plantarum在UC中的治疗应用是有必要的.
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