尿路代谢,遗传易感性,以及它们对2型糖尿病的相互作用
Weiya Li1, Zhaoyang Li1, Yan Yan1
1Department of Occupational and Environmental Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chemosphere
|October 27, 2023
概括
较低的代谢效率,即较高的无机 (iAs) %和较低的单甲基氨酸 (MMA) %,与2型糖尿病 (T2D) 的风险增加有关. 影响代谢的遗传因素可以改变这种关联.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 遗传流行病学遗传流行病学
背景情况:
- 越来越多的证据将代谢与2型糖尿病 (T2D) 联系起来,但流行病学数据不一致.
- 对代谢的遗传倾向和有关T2D风险的暴露之间的相互作用仍然不清楚.
研究的目的:
- 评估代谢效率 (iAs%,MMA%,DMA%) 和T2D风险之间的关联.
- 研究与代谢相关的遗传风险评分 (GRS) 和代谢效率之间的关系.
- 检查GRS和暴露在T2D发展中的相互作用.
主要方法:
- 一个病例控制研究,涉及996对新发型T2D病例和来自东-通吉队列的对照.
- 留下一个漏洞分析来评估代谢效率和T2D风险.
- 基于79个SNP的GRS和加权GRS (wGRS) 的计算;GRS与代谢关联的线性回归;GRS与相互作用分析的后勤回归.
主要成果:
- 尿液中较高的无机 (iAs%) 与T2D风险积极相关 (OR=1.06,95% CI:1.01-1.12).
- 较低的MMA% (OR=0.87,95%CI:0.78-0.97) 和较低的甲基化指数 (PMI) (OR=0.64,95%CI:0.47-0.86) 与T2D风险负相关.
- 与代谢相关的GRS/wGRS与MMA%正相关,与DMA%负相关.
- 对代谢的遗传倾向显著改变了无机和T2D风险之间的关联 (P-相互作用=0.033).
结论:
- 降低初级代谢效率 (较高的iAs%,较低的MMA%) 可能会增加T2D风险.
- 影响代谢的遗传因素与代谢效率有关,可以调节无机对T2D风险的影响.
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