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用Inulae Herba准Keap1激活了Nrf2受体,以减轻LPS介导的急性肺损伤

Juan Zhang¹, Jing Liu², Jing-Wen Liu²

¹Second Affiliated Hospital, Dalian Medical University, Dalian, 116044, China; College of Pharmacy, Dalian Medical University, Dalian, 116044, China; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518061, China.

Journal of ethnopharmacology

|October 27, 2023

概括

伊努拉叶草 (IH) 通过减少炎症和氧化来预防急性肺损伤 (ALI). 它针对Keap1激活Nrf2,为ALI提供潜在的草药治疗.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
传统中国医药传统中国医药

背景情况:

伊努拉草 (IH),被称为金飞,在中国医学中用于治疗肺部疾病.
它对急性肺损伤 (ALI) 的保护机制在很大程度上仍未被定义.

研究的目的:

在脂聚糖 (LPS) 诱导的ALI小鼠模型中研究IH的抗炎和抗氧化作用.
阐明IH在治疗ALI的基础分子机制.

主要方法:

脂聚糖 (LPS) 诱导的ALI小鼠模型.
西部斑点,qPCR,流细胞计,小RNA干扰,免疫组织化学,双露西法酶试验.
对巨细胞极化和Keap1-Nrf2通路激活的分析.

主要成果:

IH治疗减轻了LPS诱导的肺病理,包括水和拥堵.
IH调节了巨细胞极化,从M1转移到M2表型.
IH抑制了M1标记物 (iNOS,IL-6) 和促进了M2标记物 (ARG1,RETNLA).
通过准Keap1,IH激活了Nrf2通路,显示出抗炎和抗氧化作用.

结论:

伊努拉草 (Inulae Herba) 通过准Keap1并激活Nrf2.2来缓解LPS诱导的ALI.
IH具有显著的抗炎和抗氧化特性.
IH显示出作为开发抗ALI药物的治疗剂的潜力.

关键词:

阿里阿里是什么意思?炎症炎症是一种炎症.伊努拉 (Inulae Herba) 是一种草本植物.凯普1号码是什么意思

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