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Updated: Jul 12, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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APR-246增加了瘤抗原性,独立于p53

Judith Michels1,2, Divya Venkatesh1,2, Cailian Liu1,2

  • 1Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.

Life science alliance
|October 27, 2023
PubMed
概括

APR-246增强了瘤细胞的免疫性,提高了T细胞的反应和疫苗的疗效,即使在p53缺乏的瘤中. 将APR-246与免疫激动剂结合起来,可以产生显著的抗瘤效应,提供了p53独立的治疗策略.

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