抗菌素耐药性的全球负担 - 尿路感染
Sibylle Von Vietinghoff1, Olga Shevchuk2, Ulrich Dobrindt3
1University Hospital Bonn, Medical Clinic 1, Section for Nephrology and University Bonn, Germany.
概括
抗菌素耐药性 (AMR) 是一个日益增长的威胁,特别是在由格拉姆阴性细菌引起的尿路感染 (UTI) 中. 需要新的策略,包括抗微生物和细菌菌体,以对抗耐药性尿路病原体.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球卫生问题,由抗生素的使用加快,特别是在格拉姆阴性病原体.
- 尿路感染 (UTI) 经常是由格拉姆阴性细菌引起的,这些细菌具有高度适应性,并具有特定的毒性和AMR因子.
- 泌尿病原体中耐药性和毒性之间的相互作用是复杂的,β-乳糖酶是AMR的主要机制.
研究的目的:
- 总结关于尿路感染中临床和微生物AMR的当前知识.
- 讨论影响尿路感染中AMR患病率的因素,包括抗生素消耗和尿路生理学.
- 探索创新的非抗生素方法来对抗尿病原菌微生物.
主要方法:
- 审查关于尿路感染中抗菌素耐药性的现有文献.
- 分析导致AMR出现的因素,如抗生素史和宿主-病原体相互作用.
- 对抗微生物和细菌菌体等替代治疗方法的评估.
主要成果:
- 尿路感染中的AMR受患者群体,抗生素史和尿路疾病的影响.
- 泌尿病原体表现出复杂的机制来获得毒性和AMR.
- 抗微生物和细菌疗法显示出作为抗生素替代品的希望.
结论:
- 在尿路感染中解决AMR需要一种超越传统抗生素的多方面的方法.
- 创新策略,包括风险预测和非抗生素疗法,对于未来的尿路感染管理至关重要.
- 对抗微生物和细菌菌体进行进一步的研究是有必要的,以有效治疗耐药尿路病原体感染.
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