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一个胃口的攻击性行为? 女老鼠也从赢得攻击性互动中获得奖励

Stina Börchers^1,2, Jil Carl¹, Katharina Schormair¹

¹Department of Physiology, Institute for Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Translational psychiatry

|October 27, 2023

概括

雌性老鼠表现出侵略性,并发现赢得侵略性的遭遇是有回报的,类似于雄性. 这种行为是多巴胺依赖的,挑战了以前的研究偏见.

科学领域:

神经生物学神经生物学神经生物学
行为神经科学行为神经科学
动物行为动物行为

背景情况:

侵略通常被视为由资源驱动,但可以本质上是有回报的.
关于侵略神经生物学的研究主要集中在男性身上,忽视了女性.
在理解女性侵略及其潜在的奖励机制方面存在差距.

研究的目的:

为了调查完整的处女雌性大鼠是否会从侵略性互动中获得回报.
为了评估雄性和雌性大鼠的攻击性寻求行为.
确定多巴胺信号在侵略的奖励方面发挥的作用.

主要方法:

在老鼠中测量了半边际多巴胺的循环.
在雄性和雌性老鼠中评估了寻求攻击行为的行为.
研究了多巴胺信号传递对于寻求侵略的必要性.

主要成果:

雌性老鼠表现出非母性的侵略性.
赢得激进的遭遇对雌性老鼠来说是有回报的,与雄性相比.
多巴胺信号传递对于表达寻求侵略行为的表达至关重要.

结论:

雌性老鼠从事侵略,并从中获得奖励,类似于雄性.
两性中寻求侵略的行为都受到多巴胺的调节.
这项研究强调了将女性受试者纳入侵略性研究的重要性.

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