一个双向的门德尔随机化研究,以评估身体构成和听力损失之间的关系
Yiyan He1, Ville Karhunen2,3, Anna Pulakka2,4
1Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. Yiyan.He@oulu.fi.
Scientific reports
|October 27, 2023
概括
这项研究没有发现有力的证据表明听力损失介导了噪音暴露和肥胖之间的联系. 然而,与年龄相关的听力损失可能会对身体构成产生负面影响.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 听力学 听力学是指听力学.
背景情况:
- 听力损失与非听力健康问题有关.
- 听力功能在噪音和肥胖相关性中的作用尚不清楚.
- 门德尔随机化 (MR) 可以探索身体构成和听力障碍之间的因果关系.
研究的目的:
- 调查身体构成 (BMI,WC,BFP) 和听力障碍 (神经传感,噪音引起,与年龄相关) 之间的因果关系.
- 评估听力功能是否调解噪音与肥胖的关联.
- 使用MR探索双向因果关系.
主要方法:
- 利用了来自欧洲成年人的全基因组关联研究总结统计数据 (N=210,088360,564).
- 应用孟德尔随机化 (MR) 进行前向和反向分析.
- 在FTO位点进行了BMI和与年龄相关的听力损失 (ARHI) 的同声分析.
- 采用随机效应逆方差加权方法和灵敏度分析.
主要成果:
- 局部化分析表明,BMI和ARHI的FTO基因有一个共同的因果变异.
- 没有发现强有力的证据表明身体构成因果影响听力损失.
- ARHI与BMI和身体脂肪百分比有负面关联,这表明ARHI可能会恶化身体构成.
- 听力损失似乎没有调解噪音暴露与身体构成之间的关联.
结论:
- FTO基因可能在BMI和ARHI之间的关联中发挥作用.
- 有证据表明,与年龄相关的听力损失可能会对身体构成产生负面影响.
- 听觉功能不太可能成为噪音与肥胖关系的重要调解者.
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