COVID-19和艾滋病毒/艾滋病的同时感染动态
Tesfaneh Debele Batu1, Legesse Lemecha Obsu2, Chernet Tuge Deressa3
1Department of Applied Mathematics, Adama Science and Technology University, Adama, Ethiopia.
Scientific reports
|October 27, 2023
概括
COVID-19和人类免疫缺陷病毒 (HIV) 的联合感染带来了重大风险,特别是对于晚期HIV感染者来说. 数学建模和埃塞俄比亚数据分析显示,增加疫苗接种和治疗率可以减少同时感染的死亡人数.
科学领域:
- 流行病学和数学建模 流行病学和数学建模
- 传染病的动态传染病的动态.
背景情况:
- 冠状病毒疾病2019 (COVID-19) 和人类免疫缺陷病毒 (HIV) 仍然是重大的公共卫生挑战,同时感染对免疫功能低下的人构成特别威胁.
- 晚期艾滋病毒感染者是易受伤害的人群,在与COVID-19同时感染时面临严重后果的高风险.
- 缺乏治愈艾滋病毒的方法和可能出现复发的COVID-19感染,需要了解共同感染的动态.
研究的目的:
- 调查干预策略对COVID-19和HIV联合感染结果的影响.
- 确定影响COVID-19感染HIV感染者的死亡风险的关键参数.
- 使用数学模型分析COVID-19和HIV联合感染的传播动态.
主要方法:
- 开发和严格分析COVID-19和HIV联合感染的数学模型.
- 建立模型的不变区域,积极性和局限性.
- 计算生殖数量,检查平衡,并分析COVID-19子模型的向后分叉.
- 使用埃塞俄比亚数据进行参数估计,随后进行数值模拟,以评估参数效应和干预影响.
主要成果:
- 与艾滋病毒患者暴露和传染性增加相关的参数与较高的同时感染率有积极的相关性.
- 增加的COVID-19疫苗接种率 ([公式:见文本]) 表明对共感染病例有抑制作用.
- 在同时感染的个体中,提高COVID-19的治疗率 ([公式:见文本]和[公式:见文本]) 显著降低了死亡风险.
- 在COVID-19子模型中的向后分叉表明,R0小于1不足以消除疾病.
结论:
- 改善COVID-19疫苗接种计划和医疗干预措施对于降低艾滋病毒感染者COVID-19相关死亡率至关重要.
- 针对性干预,以解决艾滋病毒患者感染率和暴露率的增加,对于控制共感染至关重要.
- 数学建模为传染病共感染的复杂动态和控制策略的有效性提供了宝贵的见解.
相关概念视频
Retrovirus Life Cycles
46.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.1K
Sexually Transmitted Infections
328
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
328
Immunodeficiency Diseases
957
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
957
Viral Recombination
23.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K
Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K


