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Updated: Jul 12, 2025

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作为KMT2A (MLL) 重组AML的新治疗点,SET-PP2A复合物

Antonella Di Mambro1, Yoana Arroyo-Berdugo1, Tiziana Fioretti2

  • 1School of Life and Health Sciences, University of Roehampton, London, UK.

Oncogene
|October 27, 2023
PubMed
概括

酸酶PP2A的抑制剂SET在KMT2A重组的急性髓性白血病 (AML) 中过度表达. 用FTY720抑制SET会阻止白血病细胞的生长,并增强化疗敏感性,提供一种新的治疗策略.

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